| Anesthetics | Anti-inflammatories | Neuromodulators | Myomodulators | Opioids | Other |
|---|---|---|---|---|---|
|
Bupivicaine 2% 3% Lidocaine 2% 5% 10% Prilocaine 2% 2.5% Tetracaine 2% |
Diclofenac 1% 3% Flurbiprofen 10% 20% Ibuprofen 10% 20% Ketoprofen 5% 10% Piroxicam 1% 2% |
Amitriptyline 2% 3% 5% Carbamazepine 5% Clonidine 0.1% 0.2% Dextromethorphan5% Gabapentin 2.5% 5% 6% Imipramine 3% Lamotrigine 2.5% Topiramate 2.5% |
Baclofen 2% 5% Cyclobenzaprine 2% 3% Guaiafenesin 20% Magnesium Cl 10% Orphenadrine 5% |
Ketamine 4% 5% 10% Loperamide 5% Tramadol 5% |
Aminophylline 2% (vasodilator) Betamethasone 0.1% (corticosteroid) DMSO 10% (arthritis) Doxepin 5% (pruritis) Misoprostol 0.0024% (wound care) Naltrexone 1% (pruritis) Nifedipine 2% (colorectal) Nitroglycerin 0.2% (colorectal) Pentoxyfylline 5% (vasodilator) Phenytoin 5% (wound care) |
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| Drug Name | Mechanism of action | Concentrations used topically | Type of Pain |
|---|---|---|---|
| Acyclovir | Anti-viral | 5% | Herpes zoster Herpes simplex Postherpetic neuralgia |
| Amantadine | NMDA antagonist | 5 - 20% | |
| Aminophylline | 2% | Vasodilation | |
| Amitriptyline | Exact mechanism of action unknown (possible neural membrane stabilization) | 2 - 10% | Neuropathic pain Postherpetic pain |
| Baclofen | GABA-β agonist Muscle relaxant Antispasmodic agent | 1 - 5% | Neuropathic pain Multiple sclerosis Postherpetic pain |
| Betamethasone | Corticosteroid | 0.1% | Scar treatment |
| Bupivicaine | Local anesthetic Neural membrane stabilization | 2-5% | Neuropathic pain |
| Camphor | |||
| Carbamazepine | Sodium channel blocker | 5% | Neuropathic pain |
| Clobetasol | Corticosteroid | 0.05% | Scar treatment |
| Clonidine | α-2 antagonist (blocks norepinephrine receptors) | 0.1%- 0.2% | Acute or neuropathic pain |
| Cyclobenzaprine | Muscle relaxant Neural membrane stabilization (structurally similar to tricyclic antidepressants) | 1 - 3% | Neuromuscular pain Multiple sclerosis Fibromyalgia Muscle strains |
| Dextromethorphan | NMDA antagonist | 5% - 10% | |
| Diclofenac | NSAID | 1 - 10% | Pain caused by inflammation |
| Diltiazem | Ca++ channel blocker | 1 - 10% | |
| DMSO | Anti-inflammatory | 2 - 10% | Pain caused by inflammation |
| Doxepin | Tricyclic Na+channel blocker Antihistamine | 5% | Pruritis |
| Flurbiprofen | NSAID | 5 - 10% | Pain caused by inflammation |
| Gabapentin | Glutamate inhibition NMDA antagonist Neural membrane stabilization | 5 - 10% | Neuropathic pain Postherpetic pain |
| Guaifenesin | Skeletal muscle relaxant | 10 - 40% | Musculoskeletal pain Multiple sclerosis Fibromyalgia Sports injuries |
| Haloperidol | 0.5 - 2% | ||
| Ibuprofen | NSAID | 10 - 40% | Pain caused by inflammation |
| Imipramine | Exact mechanism of action unknown (possible neural membrane stabilization) | 3% | Neuropathic pain Postherpetic pain |
| Indomethacin | NSAID | 10 - 40% | Pain caused by inflammation |
| Ketamine | NMDA antagonist | 5 - 10% | Acute pain Neuropathic pain |
| Ketoprofen | NSAID | 5 - 50% | Pain caused by inflammation |
| Lamotrigine | Anticonvulsant | 3% | |
| Lidocaine | Local anesthetic Neural membrane stabilization | 2 - 10% | Neuropathic pain |
| Loperamide | Opioid agonist | 1% | |
| Magnesium Cl | Muscle relaxant | 10% | Musculoskeletal pain |
| Menthol | |||
| Misoprostol | Prostaglandin E1 analogue | 0.00024% | Wound healing |
| Naltrexone | 1% | Pruritus | |
| Nifedipine | Ca++ channel blocker NMDA antagonist Vasodilator | 2 - 16% | Anal fissure Wound healing |
| Nitroglycerin | Vasodilator | 0.2% | Anal fissure |
| Orphenadrine | NMDA antagonist Muscle relaxant | 5 - 10% | Acute pain Neuropathic pain Neuromuscular pain Multiple sclerosis Fibromyalgia |
| Pentoxifylline | TNF-1α antagonist | 5 - 10% | Inflammatory processes Neuropathic pain Wound healing Scar treatment |
| Phenytoin | 2 - 10% | Wound healing | |
| Piroxicam | NSAID | 0.5 - 1% | Inflammation SPorts injuries |
| Prilocaine | Local anesthetic Neural membrane stabilization | 2 - 2.5% | Neuropathic pain |
| Tetracaine | Local anesthetic Neural membrane stabilization | 0.5 - 10% | Neuropathic pain |
| Topiramate | 1% | ||
| Tramadol | Opioid agonist | 5% | |
| Verapamil | Ca++ channel blocker | 8% | Neuropathic pain Scar treatment |